a tool for identifying drug-targetable redox-active disulphides

Angiogenin-4

Intramolecular

Cysteine 49 and cysteine 103

A redox-regulated disulphide may form within Angiogenin-4 between cysteines 49 and 103 (25 and 79 respectively in this structure).

Details

Redox score ?

82

PDB code

Structure name

biological and structural features of murine angiogenin-4, an angiogenic protein

Structure deposition date

2006-09-05

Thiol separation (Å)

2

Half-sphere exposure sum ?

86

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

49

Residue number B

103

Peptide name

Angiogenin-4

Ligandability

Cysteine 49 of Angiogenin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 103 of Angiogenin-4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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